Unlocking the Code to Precise Quantification of ADC Therapeutics: A Comprehensive Analysis of Cutting-Edge Technologies
SDM Bioservices has successfully established a hybrid immuno-capture LC-MS/MS platform for the simultaneous quantification of ADC total antibody, conjugated antibody, conjugated drug, and free small-molecule payload. This approach significantly reduces reliance on specific antibody reagents, enables rapid method development and validation, and supports high-throughput sample analysis—thereby accelerating project timelines and advancing drug development efforts.
